The Nrf2 Activator, tBHQ, Differentially Affects Early Events Following Stimulation of Jurkat Cells
نویسندگان
چکیده
منابع مشابه
The Nrf2 activator, tBHQ, differentially affects early events following stimulation of Jurkat cells.
Nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcription factor that is activated by cellular stresses, such as oxidative compounds. After activation, Nrf2 induces transcription of its target genes, many of which have cytoprotective functions. Previously, we have shown that activation of Nrf2 by tert-butylhydroquinone (tBHQ) skews murine CD4⁺ T-cell differentiation. Although the ro...
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The transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2) regulates a battery of antioxidant, detoxification, and cell stress genes. It is activated by oxidative stress and a number of exogenous compounds, one of which is tert-butylhydroquinone (tBHQ), a widely used food preservative. Nrf2 modulates immune responses in numerous rodent models of inflammation, but its effects on...
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ژورنال
عنوان ژورنال: Toxicological Sciences
سال: 2013
ISSN: 1096-6080,1096-0929
DOI: 10.1093/toxsci/kft172